منابع مشابه
Antiviral agents: structural basis of action and rational design.
During the last 30 years, significant progress has been made in the development of novel antiviral drugs, mainly crystallizing in the establishment of potent antiretroviral therapies and the approval of drugs inhibiting hepatitis C virus replication. Although major targets of antiviral intervention involve intracellular processes required for the synthesis of viral proteins and nucleic acids, a...
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The discovery and development of more than a dozen drugs in the past 15 years for the treatment of AIDS offer an excellent example of progress in the field of rational drug design. At this time, the principal targets are reverse transcriptase and protease, enzymes encoded by the human immunodeficiency virus. The introduction of protease inhibitors, in particular, has drastically decreased the m...
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Two integer-programming models are presented which optimize barge groupings into cost efficient configurations for transit. First a grouping IP is used to cluster barges with similar characteristics such as origin port, destination port, and pickup time so as to minimize dwell and handling cost. Next an assignment IP is used to assign groups to tow boats to minimize travel costs.
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This study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (TS) inhibitor. The designed scaffold is a combination of nucleobase, amino acid and aziridine structures. The candidates are docked into TS and three DNA double strand structures and evaluated based on their binding interaction energies and ligand efficienci...
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ژورنال
عنوان ژورنال: Alexandria Engineering Journal
سال: 2019
ISSN: 1110-0168
DOI: 10.1016/j.aej.2019.09.005